Anti-tumor immunotheraphy, tolerance, asthma, mucosal vaccination
Prof. Chang-Yuil Kang
Current Research Interests
A two-pronged approach, generating effective immune responses against tumor antigen and overcoming tumor-immune suppressive environment, is required for successful cancer immunotherapy. For this, we are developing the strategies to elicit potent anti-cancer immune responses and to get over immune suppressive environment.
T cell and NKT cell
IL-17-secreting T cells represent a distinct CD4+ effector T cell lineage (Th17) that appears to be essential in the pathogenesis of numerous inflammatory and autoimmune diseases. We are studying Th17 cells in mouse and human system to characterize their immunological properties and identify new targets necessary for their generation or maintenance.
In addition, we are studying various features of natural killer T cells (NKT cells) which have a critical role in both innate and adaptive immunity. We are also studying the relationship of NKT cells with regulatory T cells.
We are studying the mechanism of immune tolerance in the periphery especially in the intestine. In this regard, our research focuses on the role of various immune cells that reside in lymphoid and non-lymphoid organs in developing immune tolerance against intestinal antigens. Also, we are studying the characteristics of diverse CD4+ T cells bearing immuno-modulating activities including Foxp3+ regulatory T cells and their role in peripheral tolerance.