Yun-Sang Lee 1 페이지

This research laboratory is affiliated with the Department of Nuclear Medicine at the Seoul National University College of Medicine. The laboratory focuses on the development of radiopharmaceuticals based on radioactive isotope-based radiopharmaceutical chemistry. They have established a technology platform for the creation of various radiolabeled compounds that enable PET, SPECT, MRI, CT, and optical imaging. The laboratory also possesses a fundamental technology for the production of radiopharmaceuticals with diagnostic and therapeutic capabilities using a radioactive isotope-labeled nanoplatform based on click chemistry reactions.

The radiopharmaceuticals developed in this laboratory are essential not only for evaluating various inflammatory diseases, metabolic disorders, and brain function, including tumor detection, but they are also widely used in disease-targeted treatments. Collaborative research with medical scientists and radiopharmacists from the Department of Nuclear Medicine at Seoul National University Hospital has led to numerous completed and ongoing clinical trials.

Furthermore, the first radiopharmaceutical developed in this laboratory, the albumin nanoplatform, has demonstrated safety. Through surface modification of albumin, it allows for the regulation of in vivo half-life and tissue distribution, enabling targeted diagnostics and treatments. The second radiopharmaceutical, the liposome nanoplatform, offers efficient drug delivery through homogeneous size control of liposomes and drug encapsulation.

In addition to these developments, ongoing research in nanomedicine at this laboratory includes the development of contrast agents using iron oxide nanoparticles and the creation of immunoreaction-based nanopharmaceuticals using antibodies. These research efforts involve collaboration among professors, graduate students, and researchers specializing in radiochemistry, biochemistry, molecular biology, and experimental animal medicine.

(1) Development of Dendritic Cell Polarization Bioimaging and Drug Delivery for Inflammatory Disease Targeted Therapy.
(2) Development of Radiopharmaceuticals for Tumor and Microenvironment Targeted Therapy Using Albumin, Liposomes, Exosomes, and Various Biodegradable Nanoparticles.
(3) Evaluation of Novel Radiopharmaceuticals' Efficacy and In Vivo Distribution Using Imaging in Various Mouse Disease Models (Tumors, Arthritis, Fibrotic Diseases, etc.).
(4) Development of Novel MR Contrast Agents Using an Iron Oxide-Based Nanoplatform.
(5) Target Discovery and Development of Novel Radiopharmaceuticals Using Alpha Nuclides for Theranostics of Recalcitrant Tumors.

1. Mannosylated-serum albumin nanoparticle imaging to monitor tumor-associated macrophages under anti-PD1 treatment. Gu, G. J., Chung, H., Park, J. Y., Yoo, R., Im, H. J., Choi, H., Lee, Y. S. & Seok, S. H., Dec 2023, In: Journal of Nanobiotechnology. 21, 1, 31.

2. Enlarged perivascular spaces are associated with decreased brain tau deposition for the KBASE Research Group, Feb 2023, In: CNS Neuroscience and Therapeutics. 29, 2, p. 577-586 10 p.

3. Imaging of Indocyanine Green-Human Serum Albumin (ICG-HSA) Complex in Secreted Protein Acidic and Rich in Cysteine (SPARC)-Expressing Glioblastoma. Jang, H. J., Song, M. G., Park, C. R., Youn, H., Lee, Y. S., Cheon, G. J. & Kang, K. W., Jan 2023, In: International Journal of Molecular Sciences. 24, 1, 850.

4. Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology for the KBASE Research Group, Dec 2022, In: Alzheimer's Research and Therapy. 14, 1, 193.

5. Association of low meal frequency with decreased in vivo Alzheimer's pathology. KBASE Research Group, 18 Nov 2022, In: iScience. 25, 11, 105422.

6. Spouse bereavement and brain pathologies: A propensity score matching study for the KBASE Research Group, Oct 2022, In: Psychiatry and Clinical Neurosciences. 76, 10, p. 490-504 15 p.

7. Circulation Time-Optimized Albumin Nanoplatform for Quantitative Visualization of Lung Metastasis via Targeting of Macrophages. Chung, H., Park, J. Y., Kim, K., Yoo, R. J., Suh, M., Gu, G. J., Kim, J. S., Choi, T. H., Byun, J. W., Ju, Y. W., Han, W., Ryu, H. S., Chung, G., Hwang, D. W., Kim, Y., Kang, H. R., Na, Y. R., Choi, H., Im, H. J., Lee, Y. S., & 1 others, 23 Aug 2022, In: ACS Nano. 16, 8, p. 12262-12275 14 p.

8. The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An18F-DOPA PET and Diffusion Tensor Imaging Studin Treatment Responsive and Resistant Patients. Shin, S., Jung, W. H., McCutcheon, R., Veronese, M., Beck, K., Lee, J. S., Lee, Y. S., Howes, O. D., Kim, E. & Kwon, J. S., Jul 2022, In: Psychiatry Investigation. 19, 7, p. 570-579 10 p.

9. [64Cu]Cu-Albumin Clearance Imaging to Evaluate Lymphatic Efflux of Cerebrospinal Space Fluid in Mouse Model. Sarker, A., Suh, M., Choi, Y., Park, J. Y., Kwon, S., Kim, H., Lee, E., Seo, H., Lee, Y. S. & Lee, D. S., Jun 2022, In: Nuclear Medicine and Molecular Imaging. 56, 3, p. 137-146 10 p.

10. Clinical Use of Radiopharmaceuticals in Boron Neutron Capture Therapy. Lee, Y. S. & Seo, H. J., Jun 2022, In: Nuclear Medicine and Molecular Imaging. 56, 3, p. 111-113 3 p.

11. KSNM60: The History of Radiopharmaceutical Sciences in Korea. Yoo, R. J., Lee, Y. S., Lee, K. C., Kim, D. W., Kim, D. Y., Choe, Y. S. & Jeong, J. M., Jun 2022, In: Nuclear Medicine and Molecular Imaging. 56, 3, p. 114-126 13 p.

12. Cerenkov luminescence imaging of interscapular brown adipose tissue using a TSPO-targeting PET probe in the UCP1 ThermoMouse. Lee, S. Y., Oh, H. R., Kim, Y. H., Bae, S. H., Lee, Y., Lee, Y. S., Lee, B. C., Cheon, G. J., Kang, K. W. & Youn, H., 2022, In: Theranostics. 12, 15, p. 6380-6394 15 p.

13. Serum zinc levels and in vivo beta-amyloid deposition in the human brain for the KBASE Research Group, Dec 2021, In: Alzheimer's Research and Therapy. 13, 1, 190.

14. Performance Evaluation of SimPET-X, a PET Insert for Simultaneous Mouse Total-Body PET/MR Imaging. Kim, K. Y., Son, J. W., Kim, K., Chung, Y., Park, J. Y., Lee, Y. S., Ko, G. B. & Lee, J. S., Oct 2021, In: Molecular Imaging and Biology. 23, 5, p. 703-713 11 p.

15. Evaluation of near-infrared fluorescence-conjugated peptides for visualization of human epidermal receptor 2-overexpressed gastric cancer. Jeong, K., Kong, S. H., Bae, S. W., Park, C. R., Berlth, F., Shin, J. H., Lee, Y. S., Youn, H., Koo, E., Suh, Y. S., Park, D. J., Lee, H. J. & Yang, H. K., Jun 2021, In: Journal of Gastric Cancer. 21, 2, p. 191-202 12 p.

16. Association of retinal changes with Alzheimer disease neuroimaging biomarkers in cognitively normal individuals. KBASE Research Group, May 2021, In: JAMA Ophthalmology. 139, 5, p. 548-556 9 p.

17. Blood Hemoglobin, in-vivo Alzheimer Pathologies, and Cognitive Impairment: A Cross-Sectional Study. KBASE Research Group, 24 Feb 2021, In: Frontiers in Aging Neuroscience. 13, 625511.

18. Prostaglandin E2receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. Na, Y. R., Jung, D., Stakenborg, M., Jang, H., Gu, G. J., Jeong, M. R., Suh, S. Y., Kim, H. J., Kwon, Y. H., Sung, T. S., Ryoo, S. B., Park, K. J., Im, J. P., Park, J. Y., Lee, Y. S., Han, H., Park, B., Lee, S., Kim, D., Lee, H. S., & 3 others, 2021, (Accepted/In press) In: Gut.

19. Synergistic Effect of Serum Homocysteine and Diabetes Mellitus on Brain Alterations. Byeon, G., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Ko, K., Jung, G., Lee, J. Y., Kim, Y. K., Lee, Y. S., Kang, K. M., Sohn, C. H. & Lee, D. Y., 2021, In: Journal of Alzheimer's Disease. 81, 1, p. 287-295 9 p.