BK21플러스 분자의학 및 바이오제약의 글로벌중개연구사업단

결과보고서

소속	BK21플러스 분자의학 및 바이오제약의 글로벌중개연구사업단
직급	박사과정	성명	강지연
승인여행기간	2017 . 02 . 26 ~ 2017 . 03 . 02
여행기간	2017 . 02 . 24 ~ 2017 . 03 . 05
여행국(도시명)	미국 (뉴욕)
여행목적	Cold Spring harbor meeting "Systems Biology: Global Regulation of Gene Expression" 에 참석
주요 방문일정	2017. 02. 24 인천공항 출발 SYSTEMS BIOLOGY: GLOBAL REGULATION OF GENE EXPRESSION Sunday, February 26– Thursday, March 2, 2017 Sunday 7:30 pm :Cis-regulatory Logic Monday 9:00 am :Chromatin Biology and 3D Architectureof the Nucleus 2:00 pm :Keynote SpeakerMonday 3:00 pm :Poster Session I 4:30 pm :Wine and Cheese Party 7:30 pm :Cellular Decision Making Tuesday 9:00 am :Evolution and Variation 2:00 pm :Transcription Factors 7:30 pm :Keynote Speaker 8:30 pm :Poster Session II Wednesday 9:00 am :RNA and Its Regulation 2:00 pm :Emerging Technologies 6:00 pm Banquet Thursday 9:00 am: Networks, Global Analysis and Computational Model 2017. 03. 04 뉴욕에서 출발 2017. 03. 05 인천공항 도착
활동내용 (보고서요약)	포스터 발표 ABSTRACT Thecancer immune-editing hypothesis emphasize that cancer cells undergo robusttransformation to reduce their immunogenicity and escape the immune recognitionthat otherwise would lead to their elimination. However, some of the anti-tumoreffects of chemotherapeutic agents are known to induce type Ι interferon (IFN)signaling pathways that enhance the immunogenicity of dying cancer cells, andthereby stimulate anti-tumor immune response. Although type Ι IFN signaling isbest known for their anti-viral interference, they are now acknowledged as oneof the key molecule to evoke cancer cell autonomous immune response that iscrucial for the therapeutic success. Upon receiving type Ι IFN signals, STAT1/2is activated by IFN receptor bound Janus kinase to regulate the induction ofdefined set of genes. Although a large number of genes are regulated in acomplex manner, how transcription factor STAT1/2 determine the finely tunedcombination of gene transcription is very unclear. So, given the growing appreciationof chromatin structure as an important element regulating gene expression, wehypothesize that STAT1/2 mediates high order chromatin structure to facilitatetranscriptional regulation by physical proximity. Here we have demonstratedthat treatment of chemotherapeutic agents trigger transcription of endogenousretroviral genes, which in turn activates cancer cell autonomous viral mimicry.We also found that finely tuned regulation of multiple gene transcription isstimulated by signal transducer and activator of transcription 1/2 (STAT1/2)mediated high-order chromatin structure. Transcriptional regulation isabrogated when physical proximity is destroyed by disruption of STAT1 binding.Overall, our results suggest that transcriptional regulation of type I IFNrelated gene signatures by STAT1/2 mediated high order chromatin structure iscrucial for the efficient anti-tumor treatment.
제출인	강지연
첨부	초청장, 프로그램, 여권사본