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Cancer epigenetics, Cancer pharmacogenetics, Molecular targeted cancer therapy Prof. Tae-You Kim
Current Research Interests
1. Molecular Target-Based Therapies
In depth molecular characterization of common cancers in Koreans (e.g. stomach, breast, lung, etc) for identifi
cation of therapeutic targets and elucidation of sensitive and resistant mechanism of molecular targeted agents. This in turn can lead to develop
ment of novel treatment strategy.
Analysis of biomarkers for effective prediction of treatment response and toxicity using clinical samples (blood and tissue) including genetic poly
morphisms and tumor expression of biomarkers.
Characterization of cancer epigenetic-related molecular mechanism and development of technology regulating gene expression in order to
develop novel drug which can regulate the expression of epigenetically silenced genes.
Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.
Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression.
A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer.
PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer.
Optimal Patient Selection for Trastuzumab Treatment in HER2-Positive Advanced Gastric Cancer